United States Department of Veterans Affairs
Research Advisory Committee on Gulf War Veterans' Illnesses

Research Update - November 2007

The following journal articles were distributed for review in November, 2007.  You can access the article's abstract by copying the paper title and pasting it into the search bar of the PubMed website, linked here. 

Research Relevant to Gulf War Service and Exposures
 
1. Military personnel in 2003 Iraq war are free from depleted uranium.  (No authors listed. BMJ.  Sep 8, 2007; 335(7618): 474
 
2. Effects of acute and repeated oral exposure to the organophosphate insecticide chlorpyrifos on open-field activity in chicks.  (Al-Badrany YM, Mohammad FK.  Toxicol Lett.  Sep 6, 2007; [Epub ahead of print])
 
3. Prevalence and correlates of posttraumatic stress disorder among Kuwaiti military men according to level of involvement in the first Gulf War.  (Al-Turkait FA, Ohaeri JU.  Depress Anxiety.  Oct 23, 2007; [Epub ahead of print]
 
4. Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints.   (Arfsten DP, et al.  J Toxicol Environ Health A.  Dec 2007; 70(23): 1995-2010)
 
5. Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.  (Bajgar J. et al.  Drug Chem Toxicol.  2007; 30(4): 351-359)
 
6. DNA fragmentation in leukocytes following repeated low dose sarin exposure in guinea pigs.  (Dave JR, et al.  Cell Mol Life Sci.  Oct 6, 2007; [Epub ahead of print])
 
7. Absence of histologic evidence of synovitis in patients with Gulf War veterans’ illness with joint pain.  (Diaz-Torne C, et al. Arthritis Rheum.  Sep 28, 2007; 57(7): 1316-1323 [Epub ahead of print])
 
8. Characteristics associated with participation in DNA banking: The National Registry of Veterans with ALS.  (DiMartino L, et al.  Contemp Clin Trials.  Sep 2007; 28(5): 572-582)
 
9. Latency: An important consideration in Gulf War syndrome.  (Friedman L, et al.  Neurotoxicology.  Aug 15, 2007; [Epub ahead of print])
 
10. Response to “Latency: An important consideration in Gulf War syndrome,” by Friedman et al.  (Heaton KJ, et al.  Neurotoxicology.  Aug 3, 2007; [Epub ahead of print])
 
11. Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorous compounds.  (Furlong CE.  J Biochem Mol Toxicol.  2007; 21(4): 197-205)
 
12. Q fever in US military returning from Iraq.  (Gleeson TD, et al.  Am J Med.  Sep 2007; 120(9): e11-e12)
 
13. Dose assessment for inhalation intakes in complex, energetic environments: experience from the U.S. Capstone study.   (Guilmette RA, Parkhurst MA.  Radiat Prot Dosimetry.  Aug 31, 2007; [Epub ahead of print])
 
14. Health services use among Gulf War veterans and Gulf War era nondeployed veterans: a large population-based survey.  (Helmer DA, et al.  Am J Public Health.  Oct 30, 2007; [Epub ahead of print])
 
15. Human metabolic interactions of environmental chemicals.  (Hodgson E, Rose RL.  J Biochem Mol Toxicol.  2007; 21(4): 182-186)
 
16. Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.  (Inman AO, et al.  J Appl Toxicol.  Oct 26, 2007; [Epub ahead of print])
 
17. Chronic fatigue syndrome and related disorders in UK veterans of the Gulf War 1990-1991: results from a two-phase cohort study.  (Ismail K, et al.  Psychol Med.   Sep 25, 2007; 1-9 [Epub ahead of print])
 
18. Glutamate receptor pathology is present in the hippocampus following repeated sub-lethal soman exposure in the absence of spatial memory deficits.  (Johnson EA, et al.  Neurotoxicology.  Sep 12, 2007; [Epub ahead of print])
 
19. Impaired mitochondrial energy metabolism and neuronal apoptoic cell death after chronic dichlorvos (OP) exposure in rat brain.  (Kaur P, et al.  Neurotoxicology.  Aug 7, 2007; [Epub ahead of print])
 
20. Neurotoxicity in murine striatal dopaminergic pathways following long-term application of low doses of permethrin and MPTP.  (Kou J, Bloomquist JR.  Toxicol Lett.  Jul 10, 2007; 171(3): 154-161)
 
21. A study of Gulf War veterans with a possible deployment-related syndrome.  (Levine PH, et al.  Arch Environ Occup Health.  Nov-Dec 2006; 61(6): 271-278)
 
22. A normative study of levels of uranium in the urine of British Forces personnel.   (Miller BG, et al.  Occup Environ Med.  Oct 12, 2007; [Epub ahead of print])
 
23. Anthrax vaccination in a military population before the war in Iraq: Side effects and informed choice.  (Murphy D, et al.  Vaccine.  Sep 19, 2007; [Epub ahead of print])
 
24. Visceral leishmaniasis: clinical observations in 4 U.S. Army soldiers deployed to Afghanistan or Iraq, 2002-2004.  (Myles O, et al.  Arch Intern Med.  Sep 24, 2007; 167(17): 1899-1901)
 
25. Depleted uranium contamination by inhalation exposure and its detection after approximately 20 years: implications for human health assessment.  (Parrish RR, et al.  Sci Total Environ.  Oct 30, 2007; [Epub ahead of print])
 
26. Altered cholinergic metabolism and muscarinic receptor linked second messenger pathways after chronic exposure to dichlorvos in rat brain.  (Raheja G, Gill KD.  Toxicol Ind Health.  Feb 2007; 23(1): 25-37)
 
27. Dermal exposure to jet fuel suppresses delayed type hypersensitivity: a critical role for aromatic hydrocarbons.  (Ramos G, et al.  Toxicol Sci.  Sep 22, 2007; {Epub ahead of print])
 
28. U.S. military deployment during 2001-2006: comparison of subjective and objective data sources in a large prospective health study.  (Smith B, et al.  Ann Epidemiol.  Oct 6, 2007; [Epub ahead of print])
 
29. An assessment of beliefs about mental health care among veterans who served in Iraq.  (Stecker T, et al.  Psychiatr Serv.  Oct 2007; 58(10): 1358-1361)
 
30. Lysophosphatidylcholine hydrolases of human erythrocytes, lymphocytes, and brain: sensitive targets of conserved specificity for organophosphorus delayed neurotoxicants.  (Vose SC , et al.  Toxicol Appl Pharmacol.  Oct 1, 2007; 224(1): 98-104)

Research on Evaluation/Treatment of Chronic Multisymptom Illnesses
 
1. First treatment for fibromyalgia approved.  (No authors listed.  Nursing.  Sep 2007; 37(9): 31)
 
2. Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study.  (Boneva RS, et al.  Auton Neurosci.  Sep 10, 2007; [Epub ahead of print])
 
3. Exercise for treating fibromyalgia syndrome.  (Busch A, et al.  Cochrane Database Syst Rev.  Oct 17, 2007; (4): CD003786)
 
4. Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach.  (Chia JK, Chia AY.  J Clin Pathol.  Sep 13, 2007; [Epub ahead of print])
 
5. Multiple chemical sensitivities: a review.  (Das-Munshi J, et al.  Curr Opin Otolaryngol Head Neck Surg.  Aug 2007; 15(4): 274-280)
 
6. Decreased central mu-opioid receptor availability in fibromyalgia.  (Harris RE, et al.  J Neurosci.  Sep 12, 2007; 27(37): 10000-10006)
 
7. Enterovirus infection of the stomach in chronic fatigue syndrome / myalgic encephalomyelitis (CFS / ME).  (Kerr JR.  J Clin Pathol.  Sep 14, 2007; [Epub ahead of print])
 
8. Characteristic electron microscopic findings in the skin of patients with fibromyalgia – preliminary study.  (Kim SH, et al.  Clin Rheumatol.  Oct 3, 2007; [Epub ahead of print])
 
9. Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widespread pain in fibromyalgia.  (Passard A, et al.  Brain.  Sep 14, 2007; [Epub ahead of print])
 
10. Melatonin therapy in fibromyalgia.  (Reiter RJ, et al.  Curr Pain Headache Rep.  Oct 2007; 11(5): 339-342)
 
11. Twin analyses of fatigue.  (Schur E, et al.  Twin Res Hum Genet.  Oct 2007; 10(5): 729-733)
 
12. Nabilone for the treatment of pain in fibromyalgia.  (Skrabek RQ, et al.  J Pain.  Oct 30, 2007; [Epub ahead of print])
 
13. Combined dexamethasone/corticotropin-releasing factor test in chronic fatigue syndrome.  (Van Den Eede F, et al.  Psychol Med.  Sep 6, 2007; 1-11 [Epub ahead of print])