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Brain Rehabilitation Research Center (BRRC)
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Center Research
The graphic below depicts a timeline with the emergence of the focused research initiatives and cores.

Human Performance |
The mission of the Human Measurement Performance Core is to develop ways to measure of human motor performance and to provide these applications to support development and refinement of effective behavioral treatments resulting from central nervous system injury or disease. Thus, the Human Performance Core provides state of the art experimental and theoretical analysis capabilities to affiliated investigators and projects in order to determine the functional impact of innovative treatments by developing methods to assess target motor functions in natural contexts. |
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| Functional Imaging |
| The mission of the Neuroimaging Core is to develop and apply functional magnetic resonance imaging (fMRI) technology in a manner that will lead to treatment innovation. Understanding the neural mechanisms of therapeutic change may require measuring neuroplastic changes in brain systems that result from neurorehabilitation, predicting the success of a given treatment within a specific patient population, and developing knowledge of brain systems and their response to injury or disease. |
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| Locomotor Intiative |
| The mission of the Locomotor Treatment Research Initiative is to maximize the recovery of locomotion in individuals with central nervous system injury or disease and to enhance their quality of life. Our aim, through research, is to apply an understanding of the neurobiological control of walking, the effect of neurologic injury on control, and experience-dependent plasticity to develop and test therapeutic training interventions that promote the recovery of walking (as opposed to compensation for locomotor deficits). |
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| Upper Extremity |
The mission of the Upper Extremity-Motor Research Initiative is to maximize the recovery of upper extremity function in individuals with central nervous system injury or disease and to enhance their quality of life. Our aim, through research, is to apply an understanding of the neurobiological control of the upper extremity and experience-dependent plasticity to develop and test therapeutic training interventions that promote the recovery of functional upper extremity skill. |
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| Oral Motor |
The mission of the Oral-Motor Research Initiative is to maximize the recovery of oral motor function in individuals with central nervous system injury or disease and to enhance their quality of life. Our aim is to develop and refine behavioral and device driven treatments for a variety of motor control disorders including Parkinson’s disease, Huntington Chorea, Multiple Sclerosis, Spinal cord injury and upper airway dysfunction due to dysarthria. Innovation is focused on the development of a device driven respiratory muscle strength re-training program and refinement includes studying the outcome of this innovation combined with other more traditional and well-studied techniques. Motor control variables are focused on systems involved in breathing, swallow, cough and speech. Finally, one area of development will be on defining new measures of speech intelligibility as it remains one of the major outcome variables of this work. |
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| Cognitive |
| The mission of the Cognitive Research Initiative is to maximize the recovery of cognitive function in individuals with central nervous system injury or disease and to enhance their quality of life. Our aim is to develop and refine mechanism-based, behavioral treatments for a variety of higher neural dysfunctions, including but not limited to aphasia, neglect, memory, aprosodia, disturbed sleep, depression and pain. Secondarily, our aim is to discover or develop dependent measures critical to documenting treatment activity. In addition, in the long term, research into alternative modes of treatment delivery and adjuvant therapies will be developed and studies crossing cognitive and motor domains will be pursued. |
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| Translational |
| The mission of the Translational Research Initiative is to translate ongoing discoveries in compensatory central nervous system responses to injury (reactive plasticity) into phase I and phase II trials of pharmacological and cellular adjuvants to behavioral rehabilitation therapy in human subjects. |
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| Reviewed/Updated Date: August 07, 2006 |
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