United States Department of Veterans Affairs
United States Department of Veterans Affairs

VA Healthcare Network Upstate New York - VISN 2

What you need to know about Drug interactions with warfarin (Coumadin®)

Doctor and Patient
Medication interactions with warfarin (Coumadin®)
Many drugs interfere with warfarin. Make sure you notify all of your health care providers that you are taking warfarin so they will know which medications can be prescribed for you. It is also important to notify your VA Coumadin Clinic with any changes in your medications or prior to starting any new medications.

How should I store my warfarin (Coumadin®) Keep your warfarin in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light.

Over the counter medications
You may take these nonprescription medications
with warfarin (Coumadin®):

acetaminophen (Tylenol®)
Chlor-Trimeton®
Contac®
Drixoril®
*Maalox®
*Mylanta®
Robitussin® Cough Syrup
Sudafed®
Tylenol Cold and Sinus®

You may not take these nonprescription medications with warfarin (Coumadin®) without your health care provider’s approval:
Alka-Seltzer®
aspirin (Bayer®, Bufferin®, Ecotrin®)
Excedrin®
ibuprofen (Advil®, Motrin®)
Naproxen (Naprosyn®, Aleve®)
Nyquil Cold®
Pepto-Bismol®

*Note: If you use antacids, such as Maalox® or Mylanta®, take them at least two hours before or two hours after taking your warfarin.

Potential interactions between herbs and warfarin (Coumadin®)

Angelica Root
Arnica Flower
Anise
Asafoetida
Bogbean
Borage Seed Oil
Bromelain
Capsicum
Celery
Chamomile
Clove
Co-enzyme Q10
Cranberry Juice
Dandelion
Danshen
Devil’s Claw
Dong Quai
Fenugreek
Feverfew
Garlic
Ginger
Ginko
Ginseng
Goldenseal
Green Tea
Horse Chestnut
Licorice Root
Lovage Root
Meadowsweet
Onion
Papain
Parsley
Passionflower
Poplar
Quassia
Red Clover
Rue
St. John’s Wart
Sweet Clover
Sweet Woodruff
Tonka Beans
Turmeric
Vitamin E
Willow Bark
Yarrow


Common prescription drug interactions with warfarin (Coumadin®)

Alcohol

Antianxiety drugs

Antiarrhythmics
amiodarone
     (Cordarone®)

Anticonvulsants
phenytoin (Dilantin®)
carbamazepine
     (Tegretol®)

Antibiotics
penicillin
ciprofloxacin
trimethoprim/
    sulfamethoxazole
     (Bactrim®)

Antidepressants

Antigout drugs
allopurinol
     (Zyloprim®)

Antineoplastics
cancer drugs

Antiplatelet drugs
clopidogrel (Plavix®)
ticlopidine (Ticlid®)

Antithyroid drugs
levothyroxine
     (Levothroid®,
     Synthroid®)

Beta-Adrenergic
Blockers
propranolol (Inderal®)

Diabetes drugs (Oral)

Diuretics
furosemide (Lasix®)

Gastrointestinal
cimetidine (Tagamet®)
omeprazole
     ( Prilosec®)

Hypolipidemics
simvastatin (Zocor®)
atorvastatin (Lipitor®)

Narcotics
hydrocodone
     (Lortab®, Vicodin®)

Steroids
prednisone


VA Coumadin Clinics
Albany (518) 626-5000
Bath (607) 664-4465
Canandaigua (585) 393-7137
Rochester (585) 463-2699
Syracuse (315) 425-2615
VA Western NY Healthcare System Buffalo Pharmacist (716) 862-7212
Patients A-L (716) 862-8764
Patients M-Z (716) 862-8763
Batavia (585) 297-1110